A new study from the University of Missouri School of Medicine is the first evidence in humans that short-term lifestyle changes can disrupt the response to insulin in the blood vessels. It’s also the first study to show that men and women react differently to these changes.
Vascular insulin resistance is a feature of obesity and type 2 diabetes that contributes to vascular disease. Researchers examined vascular insulin resistance in 36 healthy young men and women by exposing them to low physical activity for 10 days and reducing their number of steps from 10,000 to 5,000 steps per day. Participants also increased their intake of sugary drinks to six cans of soda per day.
“We know that premenopausal women have a lower incidence of insulin resistance and cardiovascular disease than men, but we wanted to see how men and women react to decreased physical activity and increased sugar in their diet over a short period of time,” Camilla said. Manrique Acevedo, MD, assistant professor of medicine.
The results showed that a sedentary lifestyle and high intake of sugar caused lower insulin-stimulated leg blood flow and a decrease in a protein called adrobin, which regulates insulin sensitivity and is an important biomarker of cardiovascular disease.
“These findings underscore the sex-related difference in the development of vascular insulin resistance caused by the adoption of a high-sugar, low-exercise lifestyle,” said Manrique Acevedo. “To our knowledge, this is the first evidence in humans that vascular insulin resistance can result from reversible short-term changes in lifestyle, and it is the first documentation of sex-related differences in the development of vascular insulin resistance in association with changes in adrobin levels.”
Manrique Acevedo said she would then like to study how long it takes to reverse these vascular and metabolic changes and to fully assess the effect of sex on the development of insulin resistance in the blood vessels.
The entire MU team consists of Jaume Padilla, Ph.D., Assistant Professor of Nutrition and Physiology and involved in this work; Luis Martinez-Lemus, DVM, Ph.D., professor of medical pharmacology and physiology, and R. Scott Rector, Ph.D., assistant professor of nutrition. It also included Postdoctoral Fellows Rogerio Soares, Ph.D.; and graduate students James A. Smith and Thomas Jurison.
Their study, “Young women are protected from vascular insulin resistance caused by adopting an obese lifestyle,” recently published in the journal Endocrinology. Part of the support for this study was provided by the National Institutes of Health and a VA Merit Grant. The content does not necessarily represent the official opinions of the funding agency. The authors declare no potential conflict of interest.
Manrique-Acevedo and her collaborators work out of the Roy Blunt NextGen Precision Health building in MU, which anchors the statewide initiative to unite government and industry leaders with innovators from all four of the system’s research universities in pursuit of critical, life-changing health advances. The University of Missouri System’s bold NextGen initiative highlights the promise of personalized healthcare and the impact of multidisciplinary collaboration at scale.
#study #involved #shortterm #exposure #reduced #activity #increased #sugar #consumption #ScienceDaily