The study found that a diet high in sugar and exercise are less harmful for men than women

The study found that a diet high in sugar and exercise are less harmful for men than women

October 31, 2022 – A new study shows that a sedentary lifestyle and excessive sugar intake have more negative effects on men than women. The men also experienced a decrease in a protein called adrobin – a key biomarker of cardiovascular disease and a regulator of insulin sensitivity.

University of Missouri School of Medicine, US The human study is the “first” to show that short-term lifestyle changes can impair the vascular response to insulin.

Furthermore, the researchers note that the study demonstrates how men and women may respond differently to these changes.

“These findings underscore the sex-related difference in the development of insulin resistance in the blood vessels caused by adopting a lifestyle high in sugar and little exercise,” says Camila Manrique-Acevedo, MD, associate professor of medicine at the University of Missouri.

“To our knowledge, this is the first evidence in humans that short-term negative lifestyle changes can elicit vascular insulin resistance, and is the first documentation of sex-related differences in the development of vascular insulin resistance in association with changes in adrobin levels.”

Obesity and type 2 diabetes are associated with vascular insulin resistance, which exacerbates vascular disease.

The effect of reduced exercise
The Researchers analysis In the short term, participants were exposed to reduced exercise and increased sugar consumption. They hypothesized that young women would be protected from vascular insulin resistance, given that the incidence of insulin resistance and cardiovascular disease is lower in premenopausal women than in men.

This is the “first” study to document how short-term lifestyle changes can lead to insulin resistance in people’s blood vessels.Manrique adds: “We know that the incidence of insulin resistance and cardiovascular disease is lower in perimenopause women than in men, but we wanted to see how men and women react to decreased physical activity and increased sugar in their diet over a short period of time” – Acevedo.

By subjecting 36 healthy young men and women to 10 days of reduced physical activity — their daily step count decreased from 10,000 to 5,000 — researchers can investigate vascular insulin resistance. The participants also increased their daily intake of sugary drinks to six cans of soda.

After decreased physical activity and increased consumption of sugar-rich soft drinks, healthy young men but not women showed a slow leg blood flow response to insulin and inhibition of skeletal muscle microvascular perfusion.

More previous research and reports
In the future, the researchers would like to look at the time it takes to reverse these metabolic and vascular changes and do a more comprehensive assessment of the effect of sex on the onset of vascular insulin resistance.

according to WHO preliminary dataWith the EU, people were more exposed to obesity risk factors such as sedentary lifestyles and consumption of unhealthy food during the COVID-19 pandemic.

Previously, a report by the Advertising Association of the UK found that sedentary lifestyles have an impact Greater effect on childhood obesity Fast food ads. The report highlighted that advertising of unhealthy foods has declined in recent years, indicating an increase in sedentary behaviour.

Edited by Nicole Kerr

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