New evidence on how sex, age and nutrition affect life

New evidence on how sex, age and nutrition affect life

  • Various factors, including gender, race, genes, and lifestyle, can affect how long a person lives.
  • In a large study in mice, researchers from the École Polytechnique Fédérale de Lausanne identified specific sex and age-dependent genes linked to longevity.
  • The scientists also found that feeding early in life significantly affected longevity in the mouse model.

Although no one can predict how long they will live, there are factors such as GeneticsAnd the lifestyleAnd the sexAnd the Sweat It can affect a person’s longevity.

Researchers from the École Polytechnique Fédérale de Lausanne in Switzerland have discovered specific sex- and age-dependent genes linked to longevity through a large-scale mouse model.

This study appears in the journal Sciences.

This study used a large-scale model of more than 3000 genetically diverse mice. Select a specific research team genetic location The physical location of a particular gene on a chromosome It is associated with longevity.

Additionally, the researchers found that some of these specific genes were different depending on whether the mouse was male or female. In addition, some genes did not affect the life span until the mouse reached a certain age. This was specifically observed in male mice.

according to Dr. Maroun Bou Suleiman d.D., a scientist in the Laboratory of Integrative Systems Physiology at the École Polytechnique Fédérale de Lausanne and lead author of the study, was not surprised to find distinct genetic loci that determine male and female longevity.

First, this appeared in other genres, in particular Drosophila black belly,” Tell Medical news today. “Second, male and female deaths are different — females live longer than males, (and) males have a wave of premature deaths due to Pressures associated with (a) the hierarchy of control. “

“Third, male and female life histories as well as immunity, endocrinology and metabolism differ,” Dr. Bou Sleiman continued. “Finally, many interventions that extend the lifespan of mice do so in a sex-specific manner. Therefore, there is a necessity to systematically assess traits such as longevity in each sex separately.”

Also through the study, Dr. Bou Sleiman and his team discovered some overlap between the genetic site of longevity and specific genes related to body weight and growth. The researchers found that, too early feeding Quality played an important role in how long a mouse lived.

“Longevity is one of the most complicated things phenotypes, because it is the end result of many interrelated processes or components, some of which may have a greater impact (on) one of the sexes. Therefore, it is not surprising that genetic influences on different processes lead to different outcomes in longevity.”

– Dr. Bou Suleiman

Considering body weight and nutrition as modifiable factors, does this prompt a debate between medical professionals and patients to improve a person’s longevity? Dr. Bou Sleiman said no – the real focus should shift from age to health, or how long a person lives free of disease.

“It is plausible that both age and healthy period share some common genetic components, so knowledge about one will inform about the other,” he explained.

“The scientific community will have to work hard to understand [relationship] Dr. added. Bou Sleiman between early nutrition, growth, health and longevity before reaching new guidelines and recommendations for “optimal” growth. “Maybe one day, we may have personalized recommendations that can be based on genetics.”

Medical news today Also talk to Dr. Scott Kaisera geriatrician and director of cognitive health on aging at the Pacific Neuroscience Institute at Providence Saint John’s Health Center in Santa Monica, California.

Dr. Kaiser said that while it’s a “very interesting study” that “reinforces the idea that longevity is really complicated,” it’s important to remember that this is still a study in mice.

“It’s a long way from a laboratory mouse model to actual, real people’s lives and unlocking the secrets of human longevity,” Dr. Kaiser explained. But these are all important steps – they are all part of the journey. Deepening the understanding of gender differences in animal models across different species is critical work.”

“This kind of work could really lead to basic biological insights, but could also be an important step in terms of informing drug discovery, which could eventually lead to new treatments, which could help people not only live longer, But live better in terms of having more years where they are lively, energetic, interactive and disease free.”

– Dr. Caesar

Dr. Kaiser agreed that there are key links between nutrition, physical activity, and longevity.

“Nutrition certainly affects longevity and may in fact affect our longevity genes,” he continued. “That should come as no surprise – if there is anything that should encourage people to focus more on healthy nutrition throughout their lives.”

However, Dr. Kaiser stresses that people shouldn’t think it’s too late to make any changes because this study points to nutrition early in life.

“All of this proves the idea that it’s certainly never too early to think about the things that can help you live well and age well,” he explained. “It is never too late to do something that can positively affect your quality of life and your lifespan. At the end of the day, the most important thing we can do now is really focus on behaviors that we know can positively affect how long we live, such as eating healthy diet (And the) Exercise Regularly.”

Prioritizing healthy relationships because we know loneliness and social isolation associated with premature death. Focus on living a full life and having a strong sense of purpose. sleeping so no smoking These are all things that we know can affect how long we live and how well we live. People need to focus on that (and) that should encourage people to keep focusing on that,” Dr. Kaiser added.

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