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Glucose diet-related metabolites associated with cognitive function in the elderly

September 19, 2022

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Granot-Hershkovitz and Sofer did not make any relevant financial disclosures. Please see the study for all relevant financial disclosures by other authors.

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Six metabolites — four linked to sugar — were consistently associated with lower global cognitive function, researchers report at Alzheimer’s disease and dementia.

Tamar Sofar, Ph.D.D., director of the Basic Program for Biostatistics in Sleep Medicine Epidemiology at Brigham and Women’s Hospital in Boston, and colleagues studied the frequency and generalization of previously identified metabolites associated with cognitive function in multiple races and ethnicities, while evaluating the contribution of diet to these associations. .

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Soffer and colleagues tested the metabolic cognitive function associated with Hispanic/Hispanic American adults (n=2222) from the Community Health Study/Latinos Study, as well as Europeans (n=1365) and Black Americans (n=478) from the Atherosclerosis Risk Study in Communities.

The authors applied randomized Mendelian analyzes to assess associations between metabolites and cognitive function, as well as between the Mediterranean diet and cognitive function.

The six reported metabolites were consistently associated with decreased global cognitive function across all races and ethnicities. One metabolite, beta-cryptoxanthin, which is closely related to fruit consumption, is associated with higher global cognitive function among Hispanic/Latino individuals.

“It is possible that these metabolites may be biomarkers of a more direct relationship between diet and cognitive function,” Einat Granot Hershkowitz, Ph.D.The study’s co-author and a postdoctoral fellow at Harvard Medical School, said in a news release from Brigham and Women’s Hospital.

According to the researchers, although there are associations between metabolites and cognitive function, their results showed weak tangential effects between specific metabolites and global cognitive function.

“While the causal effect seen in our study may be weak, repeated research has shown that the Mediterranean diet is associated with better health outcomes, including cognitive health,” Sofer said in the statement. “Our study also supports the importance of a healthy diet toward protecting cognitive function, consistent with race and ethnicity.”


Diet can play a role in cognitive function across diverse races and ethnicities. Published September 16, 2022. Accessed September 19, 2022.

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