Converting 'bad' fats into 'good' fats to treat obesity and diabetes

Converting ‘bad’ fats into ‘good’ fats to treat obesity and diabetes

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Scientists are getting closer to more effective treatments for obesity. Designed by MNT; Photo by BSIP / Getty Images & Hinterhaus Productions / Getty Images
  • Obesity is a condition that can increase the risk of certain health problems, such as type 2 diabetes.
  • There are different types of fats that affect the body differently; White fat cells, for example, store extra energy, while brown fat cells help convert fats into energy.
  • A recent study found that the metabolite myristoylglycine helps convert white fat cells into brown fat cells, which may aid weight loss.

Maintaining a healthy amount of body fat is part of general well-being. It also reduces the risk of certain health problems, making it a critical factor in preventive medicine. However, experts are still looking for the best ways to help people who are working to maintain or reach a healthy body composition.

accident study Posted in metabolites I found that a specific metabolite may be vital in helping some people lose extra body weight. They found that this metabolic product can help convert fat into a form that’s easy to burn.

Everyone has unique nutritional needs, and there are different body types and weight needs. A person who is overweight is more at risk Health problems. People who are obese are more likely to develop high blood pressure, type 2 diabetes, stroke and coronary heart disease.

Wendy Lorda registered dietitian who was not involved in this current research, explained to Today’s medical news:

Since the 1980s, obesity has been increasing rapidly and is now called the plague of the modern age. This problem is closely related to other medical conditions and can lead to joint pain, cardiovascular disease, stroke or type 2 diabetes. Excess weight not only drains you a lot of energy, but also hinders easy and free movement, for example, going up stairs without shortness of breath.”

While some people can lose weight without medical intervention, others need more help from doctors to reach the right weight for them.

Experts are working to understand which medications and treatments are most effective in helping people lose weight. One area of ​​interest concerns the differences between types of fat.

Wendy Lord notes the main differences between white fat and brown fat:

“Brown fat and white fat are made of different cells. White fat is made up of large droplets of fat or fatty acids. The cells in brown fat are filled with mitochondria. Mitochondria are rich in iron, which gives brown fat its color. They are the heart of your cells. They take in nutrients like sugar and white fat.” And they break it up to produce energy.”

Brown fat vs. white fat

“Brown fat stores more energy in a smaller space than white fat. White fat sits on the waist, hips, and thighs and stores energy and releases fatty acids when fuel is needed. Prolonged overeating causes white fat cells to swell, which leads to obesity.”
– Wendy Lord

The researchers in this current study were looking for a way to help convert white adipose tissue into brown adipose tissue. To do this, they began looking for different treatments that could help boost this process.

Because they wanted to eventually transfer their research for use with people, they focused on drugs that had already been approved by the Food and Drug Administration (FDA). Finding the right medication to focus on involves an extensive and specific screening process. Their research used cell cultures and many different testing methods.

It found that the FDA-approved drug, zafirlukast, was effective in converting white adipose tissue into brown adipose tissue. However, researchers note that zafirlukast is actually toxic to people at higher doses, which makes using the drug itself dangerous.

Digging deeper, they discovered a unique metabolite called myristoylglycine that was produced when zafirlukast turned white fat cells into brown fat cells.

Upon further testing, they found that the myristoylglycine molecule could do the same job as zafirlukast on its own but without being cytotoxic.

This discovery may lead to a new way to treat obesity and reduce people’s risk of a variety of problems. Unstudy author Dr.. Samir Moralia specialist in obesity medicine at UTHealth Houston and Memorial Hermann, to MNT:

“Myristoylglycine represents a potential therapy that would essentially act as a ‘fat burner’, converting white fat cells from fat-storage facilities into fat-burning fat cells.”

“If this discovery is able to produce a treatment that safely converts white adipose tissue into bright adipose tissue, it would represent a fundamental shift in our current treatment paradigm. It would not only represent a significant opportunity for treating obesity, but would also have the potential to positively impact more than 200 obesity-related cases.”
– Dr. Samir Morali

The study has some limitations. For example, only use cell cultures, so extensive research is still needed before we know if the results have any potential application to people.

Researchers will need to prove the drug’s efficacy and safety in people and eventually in clinical trials before it becomes clear whether this discovery may be beneficial for humans. If this metabolite is used as a treatment, it may only be suitable for use in specific people.

d p. Murali noted several components for further research and considerations. He said that while the study and its results showed “enormous potential,” more work was needed “to demonstrate the safety of myristoylglycine as a potential treatment.”

“For example, the authors note that existing medications such as rosiglitazone, known to have the same effect, have been shown to increase the risk of cardiovascular disease. It is unclear whether myristoylglycine would have similar adverse effects on other tissues, he said. It was taken as medicine.” MNT.

Currently, these results are limited to showing the ‘brown color’ of white fat cells in laboratory conditions. The next step will be to demonstrate that this can be safely reproduced in animals before it is considered a viable treatment in humans.”
– Dr. Samir Morali

Overall, this research is an important step toward expanding treatment options to help people reach an appropriate body weight. As research progresses, it could help improve health outcomes for many.

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